β-l-Aspartyl-l-histidine, a Normal Constituent of Human Urine
نویسندگان
چکیده
منابع مشابه
2-Fluoro-l-histidine
The title compound, C(6)H(8)FN(3)O(2), an analog of histidine, shows a reduced side-chain pK(a) (ca 1). The title structure exhibits a shortening of the bond between the proximal ring N atom and the F-substituted ring C atom, indicating an increase in π-bond character due to an inductive effect of fluorine.
متن کاملSusceptibility of Escherichia coli to L-selenaproline and other L-proline analogues in laboratory culture media and normal human urine.
AIMS The aims of this study were to identify analogues of L-proline which inhibit the growth of Escherichia coli in both laboratory culture media and normal human urine and to study their mechanisms of uptake. METHODS AND RESULTS The susceptibility of E. coli to L-proline analogues was studied by radial streak assays on agar plates and by minimal inhibitory concentration determinations in liq...
متن کاملThe Mammalian Metabolism of L-Histidine
The major pathway of histidine metabolism in animals and bacteria other than incorporation into protein involves first deamination to urocanic acid, then the anaerobic addition of water to form an intermediate generally considered to be 4(5)imidazolone-5(4)-propionic acid (1, 2). Finally, the ring is split enzymatically to ~formiminoglutamic acid (3) which is converted to free cglutamic acid by...
متن کاملPhase-sensitive Fluorescence Study of Mono-l-aspartyl Chlorin E6
Phase-resolved fluorescence studies of a photosensitizer for photodynamic therapy, mono-L-aspartyl chlorin e6 (ME2906), have been carried out. The experiments were done for its water solutions in the concentration range from 3.13x10 to 8.00x10 M, and some photophysical parameters have been experimentally determined for the lowest singlet excited state of ME2906. It was confirmed that ME2906 mol...
متن کاملRole of Polymeric Endosomolytic Agents in Gene Transfection: A Comparative Study of Poly(l-lysine) Grafted with Monomeric l-Histidine Analogue and Poly(l-histidine)
Endosomal entrapment is one of the main barriers that must be overcome for efficient gene expression along with cell internalization, DNA release, and nuclear import. Introducing pH-sensitive ionizable groups into the polycationic polymers to increase gene transfer efficiency has proven to be a useful method; however, a comparative study of introducing equal numbers of ionizable groups in both ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1961
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)94010-x